diff --git a/test/test_InfoExtractor.py b/test/test_InfoExtractor.py
index 31e8f82448..3fee480f39 100644
--- a/test/test_InfoExtractor.py
+++ b/test/test_InfoExtractor.py
@@ -1369,6 +1369,110 @@ jwplayer("mediaplayer").setup({"abouttext":"Visit Indie DB","aboutlink":"http:\/
                         },
                     ],
                 },
+            ), (
+                # Clear Key with CENC default_KID
+                'clearkey_cenc',
+                'https://media.axprod.net/TestVectors/v7-MultiDRM-SingleKey/Manifest_1080p_ClearKey.mpd',  # mpd_url
+                'https://media.axprod.net/TestVectors/v7-MultiDRM-SingleKey/',  # mpd_base_url
+                [{
+                    'manifest_url': 'https://media.axprod.net/TestVectors/v7-MultiDRM-SingleKey/Manifest_1080p_ClearKey.mpd',
+                    'ext': 'mp4',
+                    'format_id': '1',
+                    'format_note': 'DASH video',
+                    'protocol': 'http_dash_segments',
+                    'acodec': 'none',
+                    'vcodec': 'avc1.64001f',
+                    'tbr': 389.802,
+                    'width': 512,
+                    'height': 288,
+                    'dash_cenc': {
+                        'laurl': 'https://drm-clearkey-testvectors.axtest.net/AcquireLicense',
+                        'key_ids': ['9eb4050de44b4802932e27d75083e266'],
+                    },
+                }, {
+                    'manifest_url': 'https://media.axprod.net/TestVectors/v7-MultiDRM-SingleKey/Manifest_1080p_ClearKey.mpd',
+                    'ext': 'mp4',
+                    'format_id': '2',
+                    'format_note': 'DASH video',
+                    'protocol': 'http_dash_segments',
+                    'acodec': 'none',
+                    'vcodec': 'avc1.64001f',
+                    'tbr': 764.935,
+                    'width': 640,
+                    'height': 360,
+                    'dash_cenc': {
+                        'laurl': 'https://drm-clearkey-testvectors.axtest.net/AcquireLicense',
+                        'key_ids': ['9eb4050de44b4802932e27d75083e266'],
+                    },
+                }, {
+                    'manifest_url': 'https://media.axprod.net/TestVectors/v7-MultiDRM-SingleKey/Manifest_1080p_ClearKey.mpd',
+                    'ext': 'mp4',
+                    'format_id': '3',
+                    'format_note': 'DASH video',
+                    'protocol': 'http_dash_segments',
+                    'acodec': 'none',
+                    'vcodec': 'avc1.640028',
+                    'tbr': 1120.439,
+                    'width': 852,
+                    'height': 480,
+                    'dash_cenc': {
+                        'laurl': 'https://drm-clearkey-testvectors.axtest.net/AcquireLicense',
+                        'key_ids': ['9eb4050de44b4802932e27d75083e266'],
+                    },
+                }, {
+                    'manifest_url': 'https://media.axprod.net/TestVectors/v7-MultiDRM-SingleKey/Manifest_1080p_ClearKey.mpd',
+                    'ext': 'mp4',
+                    'format_id': '4',
+                    'format_note': 'DASH video',
+                    'protocol': 'http_dash_segments',
+                    'acodec': 'none',
+                    'vcodec': 'avc1.640032',
+                    'tbr': 1945.258,
+                    'width': 1280,
+                    'height': 720,
+                    'dash_cenc': {
+                        'laurl': 'https://drm-clearkey-testvectors.axtest.net/AcquireLicense',
+                        'key_ids': ['9eb4050de44b4802932e27d75083e266'],
+                    },
+                }, {
+                    'manifest_url': 'https://media.axprod.net/TestVectors/v7-MultiDRM-SingleKey/Manifest_1080p_ClearKey.mpd',
+                    'ext': 'mp4',
+                    'format_id': '5',
+                    'format_note': 'DASH video',
+                    'protocol': 'http_dash_segments',
+                    'acodec': 'none',
+                    'vcodec': 'avc1.640033',
+                    'tbr': 2726.377,
+                    'width': 1920,
+                    'height': 1080,
+                    'dash_cenc': {
+                        'laurl': 'https://drm-clearkey-testvectors.axtest.net/AcquireLicense',
+                        'key_ids': ['9eb4050de44b4802932e27d75083e266'],
+                    },
+                }],
+                {},
+            ), (
+                # default CENC KID overridden via W3C PSSH box, no license server in manifest
+                'w3c_pssh',
+                'https://unknown/manifest.mpd',  # mpd_url
+                'https://unknown/',  # mpd_base_url
+                [{
+                    'manifest_url': 'https://unknown/manifest.mpd',
+                    'ext': 'mp4',
+                    'format_id': '1',
+                    'format_note': 'DASH video',
+                    'protocol': 'http_dash_segments',
+                    'acodec': 'none',
+                    'vcodec': 'avc1.64001f',
+                    'tbr': 389.802,
+                    'width': 512,
+                    'height': 288,
+                    'dash_cenc': {
+                        'key_ids': ['43215678123412341234123412341234'],
+                    },
+                    'has_drm': True,
+                }],
+                {},
             ),
         ]
 
diff --git a/test/testdata/mpd/clearkey_cenc.mpd b/test/testdata/mpd/clearkey_cenc.mpd
new file mode 100644
index 0000000000..40f2123836
--- /dev/null
+++ b/test/testdata/mpd/clearkey_cenc.mpd
@@ -0,0 +1,29 @@
+<?xml version="1.0" encoding="utf-8"?>
+<!--
+Version information:
+Axinom.MediaProcessing v3.0.0 targeting General Purpose Media Format specification v7
+ffmpeg version N-81423-g61fac0e Copyright (c) 2000-2016 the FFmpeg developers
+x265 [info]: HEVC encoder version 2.0+12-49a0d1176aef5bc6
+x264 0.148.2705 3f5ed56
+MP4Box - GPAC version 0.6.2-DEV-rev683-g7b29fbe-master
+MediaInfoLib - v0.7.87
+
+For more info about this video, see https://github.com/Axinom/dash-test-vectors
+-->
+<MPD xmlns="urn:mpeg:dash:schema:mpd:2011" minBufferTime="PT1.500S" type="static" mediaPresentationDuration="PT0H12M14.000S" maxSegmentDuration="PT0H0M4.000S" profiles="urn:mpeg:dash:profile:isoff-live:2011,http://dashif.org/guidelines/dash264" xmlns:cenc="urn:mpeg:cenc:2013" xmlns:clearkey="http://dashif.org/guidelines/clearKey">
+	<Period duration="PT0H12M14.000S">
+		<AdaptationSet segmentAlignment="true" group="1" maxWidth="1920" maxHeight="1080" maxFrameRate="24" par="16:9" lang="und">
+			<ContentProtection schemeIdUri="urn:mpeg:dash:mp4protection:2011" value="cenc" cenc:default_KID="9eb4050d-e44b-4802-932e-27d75083e266" />
+			<ContentProtection value="ClearKey1.0" schemeIdUri="urn:uuid:e2719d58-a985-b3c9-781a-b030af78d30e">
+				<clearkey:Laurl Lic_type="EME-1.0">https://drm-clearkey-testvectors.axtest.net/AcquireLicense</clearkey:Laurl>
+			</ContentProtection>
+			<Role schemeIdUri="urn:mpeg:dash:role:2011" value="main" />
+			<SegmentTemplate timescale="24" media="$RepresentationID$/$Number%04d$.m4s" startNumber="1" duration="96" initialization="$RepresentationID$/init.mp4" />
+			<Representation id="1" mimeType="video/mp4" codecs="avc1.64001f" width="512" height="288" frameRate="24" sar="1:1" startWithSAP="1" bandwidth="389802"></Representation>
+			<Representation id="2" mimeType="video/mp4" codecs="avc1.64001f" width="640" height="360" frameRate="24" sar="1:1" startWithSAP="1" bandwidth="764935"></Representation>
+			<Representation id="3" mimeType="video/mp4" codecs="avc1.640028" width="852" height="480" frameRate="24" sar="640:639" startWithSAP="1" bandwidth="1120439"></Representation>
+			<Representation id="4" mimeType="video/mp4" codecs="avc1.640032" width="1280" height="720" frameRate="24" sar="1:1" startWithSAP="1" bandwidth="1945258"></Representation>
+			<Representation id="5" mimeType="video/mp4" codecs="avc1.640033" width="1920" height="1080" frameRate="24" sar="1:1" startWithSAP="1" bandwidth="2726377"></Representation>
+		</AdaptationSet>
+	</Period>
+</MPD>
diff --git a/test/testdata/mpd/w3c_pssh.mpd b/test/testdata/mpd/w3c_pssh.mpd
new file mode 100644
index 0000000000..d72cd866cd
--- /dev/null
+++ b/test/testdata/mpd/w3c_pssh.mpd
@@ -0,0 +1,13 @@
+<MPD xmlns="urn:mpeg:dash:schema:mpd:2011" minBufferTime="PT1.500S" type="static" mediaPresentationDuration="PT0H12M14.000S" maxSegmentDuration="PT0H0M4.000S" profiles="urn:mpeg:dash:profile:isoff-live:2011,http://dashif.org/guidelines/dash264" xmlns:cenc="urn:mpeg:cenc:2013" xmlns:clearkey="http://dashif.org/guidelines/clearKey">
+	<Period duration="PT0H12M14.000S">
+		<AdaptationSet segmentAlignment="true" group="1" maxWidth="1920" maxHeight="1080" maxFrameRate="24" par="16:9" lang="und">
+			<ContentProtection schemeIdUri="urn:mpeg:dash:mp4protection:2011" value="cenc" cenc:default_KID="9eb4050d-e44b-4802-932e-27d75083e266" />
+            <ContentProtection schemeIdUri="urn:uuid:1077efec-c0b2-4d02-ace3-3c1e52e2fb4b">
+              <cenc:pssh>AAAANHBzc2gBAAAAEHfv7MCyTQKs4zweUuL7SwAAAAFDIVZ4EjQSNBI0EjQSNBI0AAAAAA==</cenc:pssh>
+            </ContentProtection>
+			<Role schemeIdUri="urn:mpeg:dash:role:2011" value="main" />
+			<SegmentTemplate timescale="24" media="$RepresentationID$/$Number%04d$.m4s" startNumber="1" duration="96" initialization="$RepresentationID$/init.mp4" />
+			<Representation id="1" mimeType="video/mp4" codecs="avc1.64001f" width="512" height="288" frameRate="24" sar="1:1" startWithSAP="1" bandwidth="389802"></Representation>
+		</AdaptationSet>
+	</Period>
+</MPD>
diff --git a/yt_dlp/extractor/common.py b/yt_dlp/extractor/common.py
index 3430036f4b..1069686a95 100644
--- a/yt_dlp/extractor/common.py
+++ b/yt_dlp/extractor/common.py
@@ -14,12 +14,14 @@ import netrc
 import os
 import random
 import re
+import struct
 import subprocess
 import sys
 import time
 import types
 import urllib.parse
 import urllib.request
+import uuid
 import xml.etree.ElementTree
 
 from ..compat import (
@@ -258,6 +260,15 @@ class InfoExtractor:
                                  * ffmpeg_args_out Extra arguments for ffmpeg downloader (output)
                     * is_dash_periods  Whether the format is a result of merging
                                  multiple DASH periods.
+                    * dash_cenc  A dictionary of DASH CENC decryption information
+                                 used by the native DASH downloader when set.
+                                 * laurl    The Clear Key license server URL from which
+                                            CENC keys will be downloaded.
+                                 * key_ids  List of key IDs (as hex) to request from the ClearKey
+                                            license server.
+                                 * key      The CENC key (as hex) used to decrypt fragments.
+                                            If `key` is given, any license server URL and
+                                            key IDs will be ignored.
                     RTMP formats can also have the additional fields: page_url,
                     app, play_path, tc_url, flash_version, rtmp_live, rtmp_conn,
                     rtmp_protocol, rtmp_real_time
@@ -2669,7 +2680,10 @@ class InfoExtractor:
                 assert 'is_dash_periods' not in f, 'format already processed'
                 f['is_dash_periods'] = True
                 format_key = tuple(v for k, v in f.items() if k not in (
-                    ('format_id', 'fragments', 'manifest_stream_number')))
+                    ('format_id', 'fragments', 'manifest_stream_number', 'dash_cenc')))
+                if 'dash_cenc' in f:
+                    format_key = format_key + tuple(
+                        tuple(v) if isinstance(v, list) else v for v in f['dash_cenc'].values())
                 if format_key not in formats:
                     formats[format_key] = f
                 elif 'fragments' in f:
@@ -2703,8 +2717,18 @@ class InfoExtractor:
         def _add_ns(path):
             return self._xpath_ns(path, namespace)
 
-        def is_drm_protected(element):
-            return element.find(_add_ns('ContentProtection')) is not None
+        def extract_drm_info(element):
+            has_drm = False
+            cenc_info = {}
+            for cp_e in element.findall(_add_ns('ContentProtection')):
+                has_drm = True
+                self._extract_mpd_content_protection_info(cp_e, cenc_info)
+            info = {'dash_cenc': cenc_info} if cenc_info else {}
+            if has_drm and not (
+                cenc_info.get('key') or cenc_info.get('laurl') and cenc_info.get('key_ids')
+            ):
+                info['has_drm'] = True
+            return info
 
         def extract_multisegment_info(element, ms_parent_info):
             ms_info = ms_parent_info.copy()
@@ -2778,6 +2802,7 @@ class InfoExtractor:
                 'timescale': 1,
             })
             for adaptation_set in period.findall(_add_ns('AdaptationSet')):
+                adaptation_set_drm_info = extract_drm_info(adaptation_set)
                 adaption_set_ms_info = extract_multisegment_info(adaptation_set, period_ms_info)
                 for representation in adaptation_set.findall(_add_ns('Representation')):
                     representation_attrib = adaptation_set.attrib.copy()
@@ -2864,8 +2889,8 @@ class InfoExtractor:
                             'acodec': 'none',
                             'vcodec': 'none',
                         }
-                    if is_drm_protected(adaptation_set) or is_drm_protected(representation):
-                        f['has_drm'] = True
+                    f.update(adaptation_set_drm_info)
+                    f.update(extract_drm_info(representation))
                     representation_ms_info = extract_multisegment_info(representation, adaption_set_ms_info)
 
                     def prepare_template(template_name, identifiers):
@@ -3026,6 +3051,69 @@ class InfoExtractor:
                         period_entry['subtitles'][lang or 'und'].append(f)
             yield period_entry
 
+    def _extract_mpd_content_protection_info(self, cp_e, cenc_info):
+        """
+        Extract supported DASH-CENC parameters for an MPD ContentProtection element.
+
+        Called multiple times per extracted format in an MPD (once per ContentProtection element
+        within AdaptationSet and Representation elements). Subclasses may override this method
+        when necessary (such as when the Clear Key license server URL is provided separately
+        from the manifest or when an extractor needs to process the optional data section in W3C
+        PSSH boxes).
+
+        Note that the `has_drm` flag will be set for any format that does not meet one or more
+        of these conditions:
+
+            * Both `laurl` and `key_ids` are set (indicating the native DASH downloader should
+               use the specified Clear Key server URL to retreive the CENC key for this format.
+            * `key_id` is set (indicating the native DASH downloader should use the specified
+               CENC key for this format).
+
+        References:
+         1. DASH-IF Content Protection Identifiers
+            https://dashif.org/identifiers/content_protection/
+         2. DASH-IF Content Protection Guidelines
+            https://dashif.org/docs/IOP-Guidelines/DASH-IF-IOP-Part6-v5.0.0.pdf
+         3. W3C "cenc" Initialization Data Format
+            https://w3c.github.io/encrypted-media/format-registry/initdata/cenc.html
+        """
+        scheme_id = cp_e.get('schemeIdUri')
+        if scheme_id == 'urn:mpeg:dash:mp4protection:2011':
+            if cp_e.get('value') == 'cenc':
+                # ISO/IEC 23009-1 MPEG Common Encryption (CENC)
+                if not cenc_info.get('key_ids'):
+                    try:
+                        default_kid = uuid.UUID(cp_e.get('{urn:mpeg:cenc:2013}default_KID')).hex
+                        cenc_info['key_ids'] = [default_kid]
+                    except (ValueError, TypeError):
+                        pass
+        elif scheme_id == 'urn:uuid:e2719d58-a985-b3c9-781a-b030af78d30e':
+            # Clear Key DASH-IF
+            for tag, ns in itertools.product(
+                ('Laurl', 'laurl'),
+                ('https://dashif.org/CPS', 'http://dashif.org/guidelines/clearKey'),
+            ):
+                url_e = cp_e.find(self._xpath_ns(tag, ns))
+                if url_e is not None:
+                    cenc_info['laurl'] = url_e.text
+                    break
+        elif scheme_id == 'urn:uuid:1077efec-c0b2-4d02-ace3-3c1e52e2fb4b':
+            # W3C Common System ID
+            pssh_e = cp_e.find(self._xpath_ns('pssh', 'urn:mpeg:cenc:2013'))
+            if pssh_e is not None:
+                # W3C PSSH box (may contain Clear Key KIDs but can also be used
+                # to store KIDs for other DRM systems)
+                try:
+                    pssh_box = base64.b64decode(pssh_e.text)
+                    kid_count, = struct.unpack('!L', pssh_box[28:32])
+                    kids = []
+                    for i in range(kid_count):
+                        kid = pssh_box[32 + i * 16:32 + (i + 1) * 16]
+                        kids.append(kid.hex())
+                    cenc_info['key_ids'] = kids
+                except (ValueError, TypeError, struct.error):
+                    pass
+
     def _extract_ism_formats(self, *args, **kwargs):
         fmts, subs = self._extract_ism_formats_and_subtitles(*args, **kwargs)
         if subs: